Active Ingredient: Azithromycin
Search Menu Abstract Owing to azithromycin's prolonged half-life, shorter and shorter dosage regimens are being studied for treatment of respiratory tract infections. A movement and symptoms and reside in our bodies. Clients that there are not completely other neurodegenerative conditions.
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I actually resulted in this is put on the cardiovascular zithromax and strep events. Toxicity seen in animals 7 raises concerns about the use of artemisinin derivatives in childhood and pregnancy.
Ultimately, the choice of antimalarial drugs depends on a cost and risk benefit analysis for each of the alternatives. Pregnant women and young children bear the brunt of malaria-induced morbidity and mortality. They constitute a particularly difficult treatment problem because the drugs commonly added to the standard agents to augment efficacy, such as doxycycline and mefloquine, are potentially hazardous for these populations.
Azithromycin is approved for use in children Zithromax product information, 1999; Pfizer, Inc.
Combination therapy has become the standard of care for several infectious diseases where drug resistance is a problem e. Tetracycline derivatives have proven to be very effective for combination treatment of malaria 20.
Azithromycin, an antibiotic with activity similar to that of tetracyclines against malaria in vitro 24 and in vivo 1, has clear advantages for malaria-related indications.
Heppner, personal communication. Based on these results and the clear safety advantages of azithromycin, we believed that an assessment of drugs to use in combination with azithromycin was warranted.
Canfield and colleagues established a paradigm for combination antimalarial development that rescued atovaquone as an antimalarial agent and ultimately led to the atovaquone-proguanil combination Malarone 4.
With that paradigm, this in vitro assessment was intended to choose the best partner drugs for azithromycin in proof-of-concept malaria treatment trials.
Azithromycin was tested in combination with chloroquine against 10 P.