Active Ingredient: Orlistat
What is orlistat.
Results: After 1 y, subjects treated with 120 mg orlistat 3 times daily regained less weight than did placebo-treated subjects 32. Conclusion: The use of orlistat during periods of attempted weight maintenance minimizes weight readjustment and facilitates long-term improvement in obesity-related disease risk factors.
Obesity is a chronic disease and a major independent risk factor for cardiovascular disease 2. However, even with the most rigorous weight-loss interventions, which include behavioral modification, nutrition counseling, social support, and physical activity, these effects dissipate when weight loss is not maintained 6.
Several factors contribute to the extremely high recidivism after weight loss; these include loss of motivation and physiologic adaptations that tend to return formerly obese persons to a higher weight.
In addition, long-term weight maintenance is dependent on sustained changes in lifestyle involving dietary modification and regular physical activity.
Accordingly, long-term prevention of relapse after intentional weight loss remains a therapeutic challenge. One potential approach to preventing weight regain is to alter the absorption of energy-containing nutrients.
Orlistat Xenical; Hoffmann-La Roche, Nutley, NJ, a new antiobesity agent, works in the gastrointestinal tract to reduce dietary fat absorption.
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