Active Ingredient: Orlistat
Once the NNT and NNH values are determined, they can then be compared in a tabular or graphical form to allow some comparison among all agents. However, there is more to examining these interventions than simply considering low NNT and high NNH numbers as the markers of success.
Methods A literature search was conducted and consisted of a two-part approach. Lorcaserin, orlistat, and liraglutide, and the combination drugs phentermine—topiramate, and bupropion—naltrexone were specifically searched with this group of available papers, as these represent the most modern era of drugs that are approved as prescription weight loss regimens.
This literature review was not intended to be an exhaustive search, rather a source for obtaining background information on the medications themselves and obtaining enough trial data for the purposes of NNT and NNH calculations.
NDA applications are required to outline clinical trial information including data on efficacy, safety, adverse effects, and trial sizes.
These NDA documents are available on the internet in an unaltered form. The data pertaining to these endpoints were entered into a spreadsheet program, and calculations described above were performed to obtain the desired NNT and NNH for each medication.
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This goal is especially important in an era of harmonization. What is the active ingredient in Orlistat? Orlistat is the generic name for the active ingredient orlistat at a dose of 120 mg.
How does it work? Unlike an appetite suppressant, the drug reduces the amount of fat absorbed by your body from your food.
This active ingredient is what's known as a dietary fat binder. Contrary to popular belief, it does not bind to the fat in the food, rather it binds to the enzymes in your stomach that break down fats.
Orlistat attaches to the stomach enzyme lipase, effectively blocking it from breaking down and digesting some fat molecules. This then causes approximately one third of the fat in the meal not to be absorbed and pass through your system.