Active Ingredient: Ivermectin
Ivermectin is a derivative of Avermectin B 1, and consists of an 80:20 mixture of the equipotent homologous 22,23 dehydro B 1 a and B 1 b. Volunteers were recruited in 3 groups based on body weight.
Plasma concentrations of ivermectin were measured through HPLC up to 168 hours post treatment. Safety data showed no significant differences between groups and no serious adverse events: headache was the most frequent adverse event in all treatment groups, none of them severe.
Pharmacokinetic parameters showed a half-life between 81 and 91 h in the different treatment groups. When comparing the systemic bioavailability AUC 0 t and Cmax of the reference product WA-ref with the other two study groups using fixed doses, we observed an overall increase in AUC 0 t and Cmax for the two experimental treatments of 18 mg and 36 mg.
These findings contribute to further understand the pharmacokinetic characteristics of ivermectin, highlighting its safety across different dosing regimens.
They also correlate with known pharmacokinetic parameters showing stable levels of AUC and Cmax across a wide range of body weights, which justifies the strategy of fix dosing from a pharmacokinetic perspective.
Trial registration ClinicalTrials. Ivermectin is an antiparasitary drug which has been used to fight some of these diseases, and millions of treatments have been distributed with a favorable toxicity profile.
The dosing strategy of ivermectin is based on weight, which in view of the safety characteristics of ivermectin might not be necessary, while a fix dosing strategy might improve logistics and access to the drug to those who need it.
This study was conducted in healthy adult volunteers in which we compared 3 treatment regimens: the weight-based reference standard versus 2 experimental regimens of fix-dose 18 and 36 mg using 18 mg tablets.
All 54 volunteers received the 3 treatments sequentially. The results confirmed that the fixed-dose regimen both 18 mg and 36 mg are as safe as the standard dosage and could justify the use of fix dosing regimens rather than the current weight based strategy.
Effetti Collaterali Con Viagra.
Farmacie Online Cialis. Dapoxetine Canada - Online Pharmacy.Wearing a purple wig, however, is entirely optional. Bike-along interviews were conducted to and from a randomly chosen destination e.
Reliable meprobamate. Zyban is an antidepressant medication.
Use our online refill tool to request refills from any Aurora Pharmacy location. Conseil Achat Cialis.
Kamagra Uk Sale. A Canadian Pharmacy offering discounts on cheap prescriptions medications, order and buy your drugs online.
La parapharmacie en ligne de produits Pharmacieplemer. I am grateful to you customer service team for being so helpful when placing my order. Counting of are behind this.