Active Ingredient: Ivermectin
Show More General Information Stromectol ivermectin has been approved as a treatment for infection with nondisseminated intestinal threadworm strongyloidiasis.
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To make sure ivermectin is safe for you, tell your doctor if you have: liver or kidney disease; or cancer, HIV or AIDS, or other conditions that can weaken your immune system.
It is not known whether ivermectin will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.
Tell your doctor if you are breast-feeding a baby. Ivermectin should not be given to a child who weighs less than 33 pounds 15 kg. Acaricides that should be of historical interest, such as precipitated sulfur messy and malodorous and benzyl benzoate highly irritating, remain the only affordable option in many developing countries.
Although there are no publications confirming permethrin resistance in human scabies, anecdotal reports are increasingly common, and a laboratory population of Sarcoptes scabiei var.
A qualitative study revealed barriers to appropriate use in scabies-endemic communities in northern Australia, including a lack of privacy to undertake whole-body application, insufficient facilities to rinse the cream off, and discomfort using the cream in tropical environments.
Oral Ivermectin for Scabies These issues with topical treatment adherence meant that the addition of oral ivermectin to the scabies arsenal in the mid-1990 s was greeted with optimism.
Twenty years later, uptake of ivermectin for scabies has been relatively slow, with the primary indication being for institutional scabies outbreaks and for the treatment of severe crusted scabies, for which it has been mainly used off-label.
Ivermectin is available at relatively low cost or has been provided free or heavily subsidized by manufacturers for use in large control programmes. Meta-analyses have shown that single-dose oral ivermectin is inferior to single-dose permethrin, meaning that two doses are required for maximal efficacy.
Where two doses were given, follow-up was frequent, and community visitors were continuously screened and treated, ivermectin MDA was more successful.
Conversely, recent efforts in Australian indigenous communities with single-dose ivermectin failed to show sustained reductions in scabies prevalence.
A major limitation to the use of ivermectin for scabies is its incompletely documented safety profile in key groups. Overwhelmingly, scabies is a disease of the very young.
Surveys of clinic attendances in Australian Aboriginal communities show that most presentations occurred in the population under 2 years of age, with this age distribution supported by a recent systematic review of scabies prevalence globally.
Currently under development as an alternative treatment for onchocerciasis, moxidectin also offers promise for human scabies. New Hope with Moxidectin? Moxidectin is well established in veterinary practice to treat a range of parasites, including sarcoptic mange.