Active Ingredient: Ivermectin
However, albendazole remains the most widely used antiparasitic drugs for the treatment of this infection in this country. All patients were informed about the purpose of the trial and gave written informed consent before enrollment.
Exclusion criteria included a history of allergic reaction to either study medication, treatment within the month prior to the study with any drug known to have anti-strongyloides activity, pregnancy or lactation and any suggestion of disseminated strongyloidiasis.
Treatment Computer generated, simple, random allocation sequences were prepared for 3 study groups by the investigator team.
These were sealed in an opaque envelope and numbered. The investigator YS assigned study participants to their respective treatment group after opening the sealed envelope. Study Procedures Baseline evaluation included history, detailed physical examination, and laboratory investigations such as complete blood count CBC, urinalysis, and biochemistry.
Patients were requested to collect two consecutive fecal samples at every hospital visit.
The coprodiagnosis for the detection of S. Patients were required to make seven hospital visits to complete the study: at baseline evaluation and initiation of treatment, at 2 weeks after initiation of treatment, then at 1 month, 3 months, 6 months, 9 months, and 1 year after treatment.
Patients who completed 1 year of follow-up were invited for further follow-up visits every 3 months or at their convenience.
Outcome measures Efficacy.
The efficacy of treatment was analyzed on a modified intention to treat, and a per-protocol basis. Modified intention to treat analysis was based on the number of patients who were randomized and received treatment.
Per-protocol analysis was based on the number of patients who completed the treatment and were followed up as planned. They go through the skin, making their way through the lungs to the small intestine.
There they latch on and grow into adults, laying more eggs.