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Upregulation of interleukin IL -8 messenger RNA results in the recruitment of neutrophils manifesting clinically as inflammatory pustules.
The mite causes a cutaneous barrier disruption by eroding the epithelium. This in turn leads to a skin hypersensitivity that is reversible when the Demodex mite density is reduced with pharmacological agents.
Biopsy characteristics in a patient colonized by Demodex tend to include a dense lymphocytic infiltrate around the follicle.
Ultimately, this breach stimulates an exaggerated immune response that induces the papules and pustules characteristic of papulopustular rosacea.
The non-hemolytic S. However, in patients with papulopustular rosacea, the isolates were found to be beta hemolytic and thus more likely to produce virulence factors that stimulate the immune system.
Ultraviolet radiation increases reactive oxygen species that in turn stimulates inflammatory cytokines such as KLK 5 and cathelicidin.
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