Active Ingredient: Gabapentin
Seizures, focal partial onset immediate release only: As adjunctive therapy in the treatment of focal partial seizures with and without secondary generalization in adults and pediatric patients 3 years of age and older with epilepsy.
Off Label Uses Alcohol use disorder, moderate to severe alternative agent Data from randomized, double-blind, placebo-controlled studies support the use of gabapentin in the maintenance of abstinence in patients with alcohol use disorder,,.
By pressing a pedal that activated a motor, the force increased at a constant rate on a linear scale.
When the animal withdrew the paw or vocalized, the pedal was immediately released and the nociceptive threshold was read on a scale.
A cutoff of 250 g was used to avoid potential tissue injury. All drugs were purchased from Sigma St.
Human Study After approval was obtained from the Institutional Review Board of Wake Forest University School of Medicine, 44 patients with American Society of Anesthesiologists physical status I—III who were scheduled to undergo orthopedic or urogenital surgery during spinal or combined spinal—epidural anesthesia were recruited.
All patients provided written informed consent.
Patients taking or allergic to gabapentin were excluded, as were those with leukopenia or renal insufficiency or failure. The study was double blind.
On day 7, subjects were reassessed by the study physician.
This scale assesses the intensity of 16 symptoms which is rated by patients on a scale of 0 not at all to 4 extremely.
Among all components, we used the item of body pain for assessing the severity of pain in both the gabapentin and placebo groups 11.
Continuous variables were compared using t-test or non-parametric Mann-Whitney U-test whenever the data did not appear to have normal distribution or when the assumption of equal variances was violated across the groups.
Analyses were performed using SPSS statistical software version 16. Results and Discussion In current study, 30 men aged 26. Their findings indicate that gabapentin does not improve sleep quality assessed by the Pittsburg Sleep Quality Index.
The small dose of gabapentin and the small study sample must be considered in results interpretation.
Assessed by Spiegel score, sleep quality in our study was better in gabapentinoids groups without significant difference between gabapentin and pregabalin. Preemptive premedication with 600 mg of gabapentin or 150 mg of pregabalin improves several parameters of postoperative rehabilitation after laparoscopic cholecystectomy.
It reduces significantly the intensity of postoperative shoulder pain, decreases the incidence of PONV, improves the quality of sleep during the first night, and shortens the time to first standing position.
However, some limitations should be considered such as the nonevaluation of analgesic requirements during the postoperative period and the absence of the pharmacoeconomic component in our study.
Conclusion Preemptive premedication with gabapentin or pregabalin before laparoscopic cholecystectomy can be interesting in postoperative rehabilitation allowing ambulatory practices.
In fact, it can reduce postoperative shoulder pain and PONV incidence. It can also improve the sleep quality during the first postoperative night.
However, the optimal doses of gabapentinoids and the duration of treatment are not yet well established.
References U. Teixeira.